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OCR: 13.51) are Hamartomas of the tuber cinereum ( ecretory congenital tumours composed of neuro nich do not neurones and other neural tissue and w ently increase in size with time. They are freq often in associated with true precocious puberty, These patients younger than three years of age e posterior hamartomas are often connected with th mmillary portion of the tuber cinereum or the me by a stalk. body, or to the floor of the third ventric used to In the past, a surgical approach has been noval excise them, but their location makes re o amenable dangerous; furthermore, since they are s ent is no to GnRH agonist therapy, surgical treatr cal studies longer appropriate. Immunohistochemi have shown that the hamartomas conta GnRH-containing neurones,